Xenobiotic Laboratories (XBL), a subsidiary of the Lab Testing Division of WuXi AppTec, Inc., is a leading contract research laboratory specializing in small & large molecule Bioanalytical, drug metabolism, and pharmacokinetic services to the pharmaceutical, animal health and agrochemical industries. XBL is seeking a Research Scientist I - MET ID to join our Drug Metabolism Department.
Identification of drug metabolites using liquid chromatography-tandem mass spectrometry, NMR, and other analytical methodologies.
Elucidation of metabolic pathways involves the identification and quantification of metabolites in biological matrices (e.g., blood, plasma, excreta) using HPLC with radioactivity detection and/or LC-MS/MS.
Conduct in vivo and in vitro metabolism studies.
Conduct LC-MS/MS analysis and interpretation.
Handle radio-labeled materials (e.g., 3H, 14C).
Implements new techniques and instrumentation to improve technical operations.
Prepares scientific reports that document the analytical results and interpretation for the identification of drug metabolites.
Authors scientific papers, which are published in peer reviewed journals, and presented in scientific meetings.
Collaborate with other scientists in a team to support metabolism studies.
Knowledge of in-vitro and in-vivo drug metabolism processes and related bioanalytical techniques.
Ph.D. degree in a chemical, pharmaceutical, or equivalent
Post-doctoral experience is desirable
Any similar combination of education and experience
Experience in structural characterization and identification of drug metabolites using LC/MS/MS.
Experience and knowledge of in vivo and in vitro metabolism.
Experience with radioisotope handling (e.g., 3H, 14C) biochemical techniques is a plus.
Experience and knowledge in design of NMR experiments, operation, and data interpretation as applied to identification of unknowns is a plus.
Basic knowledge of commonly used scientific concepts, practices, and procedures within a biological or chemical R&D laboratory setting
Highly motivated with excellent communication and organizational skills
Well organized, detail oriented, and adaptable to changes
Effective oral and written communication skills
Effective interpersonal skills
Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint are desirable
Ability to learn quickly and effectively in a dynamic laboratory environment
Ability to follow instructions and research plans with limited supervision
Ability to work in a team environment
Ability to understand and adhere to regulatory guidelines consistent with XBL requirements