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Research Scientist I - MET ID (US-NJ-Plainsboro)

Overview:

  • Xenobiotic Laboratories (XBL), a subsidiary of the Lab Testing Division of WuXi AppTec, Inc., is a leading contract research laboratory specializing in small & large molecule Bioanalytical, drug metabolism, and pharmacokinetic services to the pharmaceutical, animal health and agrochemical industries. XBL is seeking a Research Scientist I - MET ID  to join our Drug Metabolism Department.
  • Key Accountibilities:

  • Identification of drug metabolites using liquid chromatography-tandem mass spectrometry, NMR, and other analytical methodologies.
  • Elucidation of metabolic pathways involves the identification and quantification of metabolites in biological matrices (e.g., blood, plasma, excreta) using HPLC with radioactivity detection and/or LC-MS/MS.
  • Conduct in vivo and in vitro metabolism studies.
  • Conduct LC-MS/MS analysis and interpretation.
  • Handle radio-labeled materials (e.g., 3H, 14C).
  • Implements new techniques and instrumentation to improve technical operations.
  • Prepares scientific reports that document the analytical results and interpretation for the identification of drug metabolites.
  • Authors scientific papers, which are published in peer reviewed journals, and presented in scientific meetings.
  • Collaborate with other scientists in a team to support metabolism studies.
  • Knowledge of in-vitro and in-vivo drug metabolism processes and related bioanalytical techniques.
  • Requirements:

  • Ph.D. degree in a chemical, pharmaceutical, or equivalent
  • Post-doctoral experience is desirable
  • Any similar combination of education and experience
  • Experience in structural characterization and identification of drug metabolites using LC/MS/MS.
  • Experience and knowledge of in vivo and in vitro metabolism.
  • Experience with radioisotope handling (e.g., 3H, 14C) biochemical techniques is a plus.
  • Experience and knowledge in design of NMR experiments, operation, and data interpretation as applied to identification of unknowns is a plus.
  • Basic knowledge of commonly used scientific concepts, practices, and procedures within a biological or chemical R&D laboratory setting
  • Highly motivated with excellent communication and organizational skills
  • Well organized, detail oriented, and adaptable to changes
  • Effective oral and written communication skills
  • Effective interpersonal skills
  • Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint are desirable
  • Ability to learn quickly and effectively in a dynamic laboratory environment
  • Ability to follow instructions and research plans with limited supervision
  • Ability to work in a team environment
  • Ability to understand and adhere to regulatory guidelines consistent with XBL requirements